“International Medical Service in Egypt.”

Fertility & Ovarian Aging

Anti-Mullerian Hormone


New Marker for Determination of Ovarian Reserve Anti-Müllerian Hormone (AMH) also known as Müllerian Inhibiting Substance (MIS) is produced by the Sertoli cells of the testis in the male and by ovarian granulosa cells in the female in a sexually dimorphic pattern that makes it a useful marker for male and female gonadal disorders.
Recent studies suggest that AMH/MIS correlates with ovarian follicular status and ovarian reserve.


Clinical Value:

Evaluating Fertility Potential — Serum AMH levels correlate with the number of early antral follicles with greater Specificity than inhibin B, estradiol, Follicle Stimulating Hormone and Luteinizing Hormone on cycle day 3. Thus, AMH may reflect ovarian follicular status better than the usual hormone markers.
Measuring Ovarian Aging — Diminished ovarian reserve, associated with poor response to in vitrofertilization, is signaled by reduced baseline serum AMH concentrations. AMH would appear to be a useful marker for predicting ovarian aging and the potential for successful IVF.

Predicting Onset of Menopause — The duration of the menopausal transition can vary significantly in individuals and reproductive capacity may be seriously compromised prior to clinical diagnosis. AMH can predict the occurrence of the menopausal transition.

Assessing Polycystic Ovary Syndrome — Serum AMH levels are elevated in patients with polycystic ovary syndrome and may be useful as a marker for the extent of the disease.

The estimation of Anti-Müllerian Hormone and Inhibin B are routinely done In alfa laboratories.


References:

Gruijters MJ, Visser JA, Durlinger AL, Themmen AP Anti-Müllerian hormone and its role in ovarian function. Mol Cell Endocrinol 2003, 211(1-2):85-90.

Fanchin R, Schondäuer LM, Righini C, Guibourdenche J. Frydman R. Taieb J. Serum anti-Mullerian hormone is more strongly related to ovarian follicular status than serum inhibinB, estradiol, FSH and LH on day 3. Hum Reprod 2003; 18(2) :323-7.

Laven JS, Mulders AG, Visser JA, Themmen AP, De Jong FH,Fauser BC. Anti-Müllerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age. J Clin Endocrinol Metab 2004;89:318-23.

 

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